Abstract:
Background: The moderated effect of flax, sunflower and pumpkin seeds are common used as edible seeds in human
nutrition. Aim: To investigate the nutritional effect of flax/sunflower/pumpkin mix seeds on hypercholesterolemia for
male albino rats by estimated biological, biochemical and histopathological examinations. Methods: The study focused
on flax/sunflower/pumpkin seeds mix powder on rat suffered from hypercholesterolemia. The feed intake, body weight
gain, feed efficiency ratio, relative liver and heart weight, lipid profile, liver enzymes, kidney function, oxidative stress
markers, lipid peroxide levels and heart histopathology for normal and hypercholesterolemic rats were examined. Main
first group (6 rats) was fed on basal diet for 12 weeks. Main second group (24 rats) fed on diet with
hypercholesterolemia for 8 weeks, then diet supplemented with mix seeds powder 3, 6 and 9%, respectively for
successive 4 weeks. Results: The results clearly demonstrate that dietary treatment with mix flax /sunflower /pumpkin
seeds (30 g; 60 g and 90 g) for 4 weeks has a powerful modulating effect to improve biological evaluation, serum blood
levels and heart tissues changes of hypercholesterolemic rats then, this mix seeds have the potential in reducing
cardiovascular diseases complications due to hypercholesterolemia. Conclusion: Flax/sunflower/pumpkin mix seeds
have modulation effect of biochemical analysis levels and improve heart tissues changes of rats. Hens, human beings
can use flax/sunflower/pumpkin mix seeds to increment high levels of lipid blood levels, liver enzymes, kidney function
and enhance heart tissues by their high nutritional content values and functional effects.
